pH‐Responsive Polymers as Gene Carriers
Identifieur interne : 002668 ( Main/Exploration ); précédent : 002667; suivant : 002669pH‐Responsive Polymers as Gene Carriers
Auteurs : In-Kyu Park [Corée du Sud] ; Kaushik Singha [Corée du Sud] ; Rohidas B. Arote [Corée du Sud] ; Yun-Jaie Choi [Corée du Sud] ; Won Jong Kim [Corée du Sud] ; Chong-Su Cho [Corée du Sud]Source :
- Macromolecular Rapid Communications [ 1022-1336 ] ; 2010-07-01.
English descriptors
- Teeft :
- Acetal linkage, Acidic, Acrylic acid, Agricultural biotechnology, Aminated, Amine, Amine functionalities, Amino groups, Arote, Binary complexes, Biocompatible sirna delivery, Bioconjug chem, Bioconjugate chem, Biomolecular engineering, Blood components, Blood stream, Buffering, Buffering capacity, Carboxylic groups, Cationic, Cationic polyplexes, Cellular compartments, Cellular uptake, Chem, Chitosan, Chitosan derivatives, Choi, Commun, Conformational change, Copolymer, Delivery process, Delivery system, Diblock copolymers, Different cell lines, Dmaema, Drug delivery, Endosomal, Endosomal compartment, Endosomal compartments, Endosomal destabilization, Endosomal membrane, Endosomal release, Endosomal rupture, Figure complexes, Functional features, Functional traits, Fusion ability, Fusion capability, Fusogenic, Fusogenic peptide, Fusogenic peptides, Fusogenic polymers, Gala peptide, Gene, Gene carriers, Gene delivery, Gene expression, Gene transfer, Gmbh, Hemolytic activity, High buffering capacity, Higher transfection, Histidine, Hydrazone, Hydrophilic, Hydrophobic, Imidazole, Imidazole group, Imidazole groups, Intracellular, Intracellular delivery, Kaushik singha, Ketal branches, Kgaa, Liposome, Macromol, Major disadvantage, Maleimide moiety, Membrane, Membrane disruption, Membrane fusion, Membrane fusion activity, Natl acad, Nucleic, Nucleic acid delivery, Nucleic acids, Pdna, Pdpa chains, Peptide, Pohang university, Polymer, Polymeric, Polymeric vectors, Polyplexes, Positive charge, Postdoctoral researcher, Potential candidates, Proton sponge effect, Protonated, Rapid commun, Reversible shielding, Secondary amines, Seoul, Seoul republic, Singha, Sirna, Target cells, Ternary complexes, Tokyo institute, Transfection, Transfection activity, Unfavorable interactions, Uorescent protein, Various kinds, Verlag, Verlag gmbh, Vesicle, Weinheim.
Abstract
Despite the immense potential of non‐viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some non‐viral vectors which are endowed with special characteristics to act differently in intracellular as well as extracellular compartments to surmount these inter‐conflicting hurdles. Such smart polymers should serve some specific purposes by adjusting their structural or functional traits under the influence of stimuli such as temperature, light, salt concentration or pH. Among all these stimuli‐responsive polymers pH‐responsive polymers have attracted major attention and great impetus has been directed towards utilizing the subtle yet significant change in pH value within the cellular compartments. This review is intended to provide a comprehensive account of the development of pH‐responsive polymeric vectors based on their structural features and consequent functional attributes to achieve efficient transfection. The underlying modes of actions relating to structure and differential pH environment have also been discussed in this review.
pH‐responsive polymers are successfully designed and developed to achieve efficient gene delivery by exploiting the subtle pH differences within the cellular compartments. Installation of appropriate functional as well as structural attributes into the basic polymeric framework could trigger favorable pH‐responsive transformations which provide enhanced gene delivery as well as higher biocompatibility.
Url:
DOI: 10.1002/marc.200900867
Affiliations:
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when="2010-07-01">2010-07-01</date></imprint><idno type="ISSN">1022-1336</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1022-1336</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetal linkage</term><term>Acidic</term><term>Acrylic acid</term><term>Agricultural biotechnology</term><term>Aminated</term><term>Amine</term><term>Amine functionalities</term><term>Amino groups</term><term>Arote</term><term>Binary complexes</term><term>Biocompatible sirna delivery</term><term>Bioconjug chem</term><term>Bioconjugate chem</term><term>Biomolecular engineering</term><term>Blood components</term><term>Blood stream</term><term>Buffering</term><term>Buffering capacity</term><term>Carboxylic groups</term><term>Cationic</term><term>Cationic polyplexes</term><term>Cellular compartments</term><term>Cellular uptake</term><term>Chem</term><term>Chitosan</term><term>Chitosan derivatives</term><term>Choi</term><term>Commun</term><term>Conformational change</term><term>Copolymer</term><term>Delivery process</term><term>Delivery system</term><term>Diblock copolymers</term><term>Different cell lines</term><term>Dmaema</term><term>Drug delivery</term><term>Endosomal</term><term>Endosomal compartment</term><term>Endosomal compartments</term><term>Endosomal destabilization</term><term>Endosomal membrane</term><term>Endosomal release</term><term>Endosomal rupture</term><term>Figure complexes</term><term>Functional features</term><term>Functional traits</term><term>Fusion ability</term><term>Fusion capability</term><term>Fusogenic</term><term>Fusogenic peptide</term><term>Fusogenic peptides</term><term>Fusogenic polymers</term><term>Gala peptide</term><term>Gene</term><term>Gene carriers</term><term>Gene delivery</term><term>Gene expression</term><term>Gene transfer</term><term>Gmbh</term><term>Hemolytic activity</term><term>High buffering capacity</term><term>Higher transfection</term><term>Histidine</term><term>Hydrazone</term><term>Hydrophilic</term><term>Hydrophobic</term><term>Imidazole</term><term>Imidazole group</term><term>Imidazole groups</term><term>Intracellular</term><term>Intracellular delivery</term><term>Kaushik singha</term><term>Ketal branches</term><term>Kgaa</term><term>Liposome</term><term>Macromol</term><term>Major disadvantage</term><term>Maleimide moiety</term><term>Membrane</term><term>Membrane disruption</term><term>Membrane fusion</term><term>Membrane fusion activity</term><term>Natl acad</term><term>Nucleic</term><term>Nucleic acid delivery</term><term>Nucleic acids</term><term>Pdna</term><term>Pdpa chains</term><term>Peptide</term><term>Pohang university</term><term>Polymer</term><term>Polymeric</term><term>Polymeric vectors</term><term>Polyplexes</term><term>Positive charge</term><term>Postdoctoral researcher</term><term>Potential candidates</term><term>Proton sponge effect</term><term>Protonated</term><term>Rapid commun</term><term>Reversible shielding</term><term>Secondary amines</term><term>Seoul</term><term>Seoul republic</term><term>Singha</term><term>Sirna</term><term>Target cells</term><term>Ternary complexes</term><term>Tokyo institute</term><term>Transfection</term><term>Transfection activity</term><term>Unfavorable interactions</term><term>Uorescent protein</term><term>Various kinds</term><term>Verlag</term><term>Verlag gmbh</term><term>Vesicle</term><term>Weinheim</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the immense potential of non‐viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some non‐viral vectors which are endowed with special characteristics to act differently in intracellular as well as extracellular compartments to surmount these inter‐conflicting hurdles. Such smart polymers should serve some specific purposes by adjusting their structural or functional traits under the influence of stimuli such as temperature, light, salt concentration or pH. Among all these stimuli‐responsive polymers pH‐responsive polymers have attracted major attention and great impetus has been directed towards utilizing the subtle yet significant change in pH value within the cellular compartments. This review is intended to provide a comprehensive account of the development of pH‐responsive polymeric vectors based on their structural features and consequent functional attributes to achieve efficient transfection. The underlying modes of actions relating to structure and differential pH environment have also been discussed in this review.</div><div type="abstract" xml:lang="en">pH‐responsive polymers are successfully designed and developed to achieve efficient gene delivery by exploiting the subtle pH differences within the cellular compartments. Installation of appropriate functional as well as structural attributes into the basic polymeric framework could trigger favorable pH‐responsive transformations which provide enhanced gene delivery as well as higher biocompatibility.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Park, In Yu" sort="Park, In Yu" uniqKey="Park I" first="In-Kyu" last="Park">In-Kyu Park</name></noRegion><name sortKey="Arote, Rohidas B" sort="Arote, Rohidas B" uniqKey="Arote R" first="Rohidas B." last="Arote">Rohidas B. Arote</name><name sortKey="Arote, Rohidas B" sort="Arote, Rohidas B" uniqKey="Arote R" first="Rohidas B." last="Arote">Rohidas B. Arote</name><name sortKey="Cho, Chong U" sort="Cho, Chong U" uniqKey="Cho C" first="Chong-Su" last="Cho">Chong-Su Cho</name><name sortKey="Cho, Chong U" sort="Cho, Chong U" uniqKey="Cho C" first="Chong-Su" last="Cho">Chong-Su Cho</name><name sortKey="Cho, Chong U" sort="Cho, Chong U" uniqKey="Cho C" first="Chong-Su" last="Cho">Chong-Su Cho</name><name sortKey="Choi, Yun Aie" sort="Choi, Yun Aie" uniqKey="Choi Y" first="Yun-Jaie" last="Choi">Yun-Jaie Choi</name><name sortKey="Kim, Won Jong" sort="Kim, Won Jong" uniqKey="Kim W" first="Won Jong" last="Kim">Won Jong Kim</name><name sortKey="Kim, Won Jong" sort="Kim, Won Jong" uniqKey="Kim W" first="Won Jong" last="Kim">Won Jong Kim</name><name sortKey="Singha, Kaushik" sort="Singha, Kaushik" uniqKey="Singha K" first="Kaushik" last="Singha">Kaushik Singha</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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